High triglycerides can have many causes, including genetics. When it's an inherited condition, it's known as familial hypertriglyceridemia. HDL cholesterol removes extra cholesterol and plaque buildup in your arteries. High cholesterol often has no symptoms, but can lead to serious health issues. Having too many triglycerides in your blood can be harmful and lead to heart disease. Here are some natural ways to lower your triglycerides. Health Conditions Discover Plan Connect. Medically reviewed by Deborah Weatherspoon, Ph.
Statins and cholesterol. Available prescriptions. Statins that you should take at night. Statins you can take in the morning. What you need to know about taking statins. Other ways to help reduce cholesterol. Read this next. The apparent circadian rhythm of cholesterol production sparked the recommendation that statins be dosed at bedtime to provide the greatest medication concentration when endogenous cholesterol production is the highest.
Investigation of pharmacokinetic properties of individual statins disproved the need for all agents to be dosed at bedtime. Simvastatin, fluvastatin, and lovastatin have a short elimination half-life compared to other drugs within the class. Agents with significantly shorter elimination half-lives require bedtime dosing to maximize efficacy - allowing the greatest statin concentration to be present while endogenous cholesterol synthesis is the highest.
Alternatively, the longer half-lives of rosuvastatin, atorvastatin, pitavastatin, and pravastatin allow these agents to maintain a therapeutic drug concentration over a hour period and allow alternate administration times.
Even if properly counseled to take statins with a shorter half-life at bedtime, some patients do not comply which may result in decreased efficacy.
Agents with longer half-lives allow for greater flexibility in administration time, which may improve compliance and ultimately result in greater LDL-C reduction and ability to achieve cholesterol goals. About Us Disclaimer Contact Us. You can choose to take it at any time, as long as you stick to the same time every day.
Sometimes doctors may recommend taking it in the evening. This is because your body makes most cholesterol at night. If you're not sure when to take your medicine, ask a pharmacist or your doctor for advice. Atorvastatin doesn't upset the stomach, so you can take it with or without food. Swallow atorvastatin tablets whole with a glass of water. If you've been given chewable tablets, you can chew them or swallow them whole with a glass of water. In children, the usual dose is 10mg to 20mg once a day.
Your doctor will use your child's age to work out the amount of atorvastatin that's right for them. Your dose depends on the reason for taking it, your cholesterol levels , and what other medicines you're taking. Ask your doctor or pharmacist for advice if you're unsure how much to take. Don't reduce your dose without talking to your doctor first. If you occasionally forget to take a dose, take your next dose the next day at the usual time. Never take 2 doses at the same time.
Never take extra doses. If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. Talk to your pharmacist or doctor if you're worried or take more than 1 extra dose. Like all medicines, atorvastatin can cause side effects in some people - and different statins affect people in different ways. One rare but serious side effect is unexplained muscle aches and pains , tenderness or weakness.
This can happen a few weeks or months after you first start taking this medicine. Talk to your doctor or a pharmacist if side effects are bothering you.
They may recommend trying an alternative statin. These common side effects of atorvastatin happen in more than 1 in people.
Some side effects may improve after the first few days, as your body gets used to the medicine. Keep taking the medicine, but talk to your doctor or pharmacist if these side effects bother you or don't go away:. Report any unexplained muscle aches and pains, tenderness or weakness to a doctor straight away. Less than 1 in people may have some memory loss. Talk to your doctor or pharmacist if this side effect bothers you. It usually goes away after you stop taking the medicine.
Serious side effects when taking atorvastatin are rare and happen in less than 1 in 1, people. In rare cases, it's possible to have a serious allergic reaction anaphylaxis to atorvastatin.
These are not all the side effects of atorvastatin. For a full list see the leaflet inside your medicines packet. Atorvastatin isn't recommended during pregnancy or breastfeeding, as there's no firm evidence it's safe.
Talk to your doctor if you want to get pregnant. It's best to stop taking atorvastatin at least 3 months before you start trying for a baby.
If you become pregnant while taking atorvastatin, stop taking the medicine and tell your doctor. It's not known if atorvastatin gets into breast milk, but it may cause problems for your baby. Speak to your doctor about what's best for you and your baby while you're breastfeeding. It may be possible to delay starting or restarting atorvastatin until you've stopped breastfeeding completely.
Some medicines affect the way atorvastatin works and can increase the risk of serious side effects. If you're taking atorvastatin and need to take one of these medicines, your doctor may:.
These are not all the medicines that can interfere with atorvastatin. Some statins work best in the evening while others work just as well in the morning. The best time to take statins depends on the specific drug. There are several different types of statin on the market, which the body may process differently. People may need to take some statins at specific times of the day to get the most benefit from them.
In this article, we look at the effects of statins at different times of the day and discuss the best times to take certain types. We also cover side effects and how a person can choose the right statin to suit their needs. They reduce the levels of LDL cholesterol in the blood. LDL cholesterol, which people sometimes refer to as bad cholesterol, can build up in the arteries and form plaque.
This plaque can block blood flow in the arteries, leading to heart attack and stroke. Statins block an enzyme in the liver that makes cholesterol, which reduces the risk of plaque buildup. Statins may also help the body remove cholesterol that has started to accumulate in the arteries.
Conversely, high-density lipoprotein HDL , or good, cholesterol can reduce the risk of heart attack and stroke. Doctors consider HDL cholesterol to be beneficial because it can transport other forms of cholesterol from the blood to the liver, which helps the body get rid of bad cholesterol. It is important that a person taking statins follows the advice of their prescribing doctor regarding the time of day to take them. The recommended time, which is something that a person should discuss with their doctor, will vary depending on the type of statin.
A systematic review found that short-acting statins worked best when people took them in the evening. The people who took these statins toward the end of the day had lower total cholesterol and LDL cholesterol levels compared with the people who took them in the morning.
Another review came to the same conclusion. Short-acting statins work better at night because the liver enzyme that produces cholesterol is more active at this time. Most short-acting statins have a half-life of 6 hours. It takes longer for the body to process long-acting statins, which may have a half-life of up to 19 hours.
The two reviews above noted that long-acting statins worked equally well whether a person took them in the morning or the evening. Therefore, people taking long-acting statins can choose which time of the day best suits them.
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