Do not share cephalexin with another person , even if they have the same symptoms you have. This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using cephalexin. Store the tablets and capsules at room temperature away from moisture, heat, and light.
Store the liquid medicine in the refrigerator. Throw away any unused liquid after 14 days. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time. Overdose symptoms may include nausea, vomiting, stomach pain, diarrhea, and blood in your urine.
Cephalexin is used to treat many types of infections. Health Topics. Health Tools. Cephalexin Keflex. Between-group adverse event rates and secondary outcomes through 7 to 9 weeks, including overnight hospitalization, recurrent skin infections, and similar infection in household contacts, did not differ significantly. Conclusions and relevance: Among patients with uncomplicated cellulitis, the use of cephalexin plus trimethoprim-sulfamethoxazole compared to cephalexin alone did not result in higher rates of clinical resolution of cellulitis in the per-protocol analysis.
However, because imprecision around the findings in the modified intention-to-treat analysis included a clinically important difference favoring cephalexin plus trimethoprim-sulfamethoxazole, further research may be needed. David Talan, MD. View Profile. Accept as Contact. Gregory Moran, MD. Peter Yarbrough, MD. David Young, MD. Gillian Schmitz, MD.
Lauri Hicks, DO. Martin Stryjewski, MD. Lead Moderators. Edward Grom. Laura Welsh, MD. The single-dose therapy had a clinical response rate equivalent to the two three-day regimens.
Gatifloxacin is also expected to be 1, times less likely than older fluoroquinolones to become resistant because of its 8-methoxy structure. Fosfomycin Monurol is another treatment option for patients with UTI. The U. A study 20 comparing a single dose of fosfomycin 3 g with a seven-day course of nitrofurantoin mg twice daily showed similar bacteriologic cure rates 60 versus 59 percent, respectively.
Increasing resistance, however, has limited their effectiveness. Cephalosporins are pregnancy category B drugs, and a seven-day regimen can be considered as a second-line therapy for pregnant women.
Ciprofloxacin Cipro. Gatifloxacin Tequin. Physicians commonly recommend nonpharmacologic options e. A Cochrane review 22 found insufficient evidence to recommend the use of cranberry juice to manage UTI. Similarly, no scientific evidence suggests that women with cystitis should increase their fluid intake, and some doctors speculate that increased fluid may be detrimental because it may decrease the urinary concentration of antimicrobial agents.
Treating older women who have UTIs requires special consideration. The study, which included outpatient and institutionalized women with an average age of approximately 80 years, showed a 96 percent bacteriologic eradication rate with ciprofloxacin compared with an 80 percent eradication rate with TMP-SMX for the three most common isolates.
The three-day therapy had a higher failure rate when compared with the seven-day regimen. The incidence of UTI in men ages 15 to 50 years is very low, and little evidence exists on treating them.
Risk factors include homosexuality, intercourse with an infected woman, and lack of circumcision. The limited available data are similar on two key points. First, the data show that men should receive the same treatment as women with the exception of nitrofurantoin, which has poor tissue penetration. After reviewing the available clinical data as of and classifying it by quality of evidence, the IDSA published guidelines for the use of antimicrobial agents to treat women with UTI.
Second, although it recognizes that they have efficacy rates similar to TMP-SMX, the IDSA does not recommend fluoroquinolones as universal first-line agents because of resistance concerns.
Third, the IDSA recommends a seven-day course of nitrofurantoin or a single dose of fosfomycin as reasonable treatment alternatives. Finally, the IDSA does not recommend the use of betalactams because multiple studies have shown them to be inferior when compared with other treatments.
Figure 1 is an algorithm for the management of uncomplicated UTIs. Algorithm for the management of uncomplicated urinary tract infections. Already a member or subscriber? Log in. Interested in AAFP membership? Learn more. She received her medical degree at the University of Oklahoma College of Medicine-Tulsa, where she also completed a family medicine residency.
Address correspondence to Susan A. Mehnert-Kay, M. Louis Ave. Reprints are not available from the author. The author thanks Karen Malnar, R. National Institutes of Health.
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